Histology and subtypes

62 values

Conditions columnSubtype filtersSearchAPI and MCP

Where the labels of a tumour differ by histology, site, grade, phase or another subtype, its page offers a choice for each, and an entry the label limits says so in the Conditions column. The label decides: the first pattern that matches the entry's tumour as labelled gives the subtypes it allows; an entry no pattern matches applies to all of them. Entries of one medicine that differ only in the tumour named (DLBCL, HGBL and PMBCL) count as one, which allows each of them. For the CML phase the label sentence counts too, and for the platinum response the eligibility, which the Conditions column shows already. A choice keeps the entries it allows and those for any subtype. Adenocarcinoma of the gastro-oesophageal junction is filed under gastric cancer and listed under oesophageal cancer too. The lists come from pathology practice; no model sets them.

Tumour	Subtypes	Label wording, first match wins	Search terms
Oesophageal cancerHistology	Squamous, Adenocarcinoma	`^(?=.junction)(?=.adenocarcinoma)` → Gastro-oesophageal junction adenocarcinoma only ×11 `squamous` → Squamous cell carcinoma only ×8 `adenocarcinoma` → Adenocarcinoma only ×1 anything else → any histology ×2	squamous cell carcinoma → Squamous; adenocarcinoma → Adenocarcinoma
Gastric and GEJ adenocarcinomaSite	Stomach, Junction (GEJ)	`gastric\|stomach` → Stomach or Junction (GEJ), not shown ×13 `junction\|oesophag\|esophag\|cardia` → Gastro-oesophageal junction only ×1 anything else → any site ×0	stomach → Stomach; gastro-oesophageal junction → Junction (GEJ)
Anal cancerHistology	Squamous, Adenocarcinoma	`squamous` → Squamous cell carcinoma only ×1 `adenocarcinoma` → Adenocarcinoma only ×0 anything else → any histology ×0	squamous cell carcinoma → Squamous; adenocarcinoma → Adenocarcinoma
Biliary tract cancerSite	Cholangiocarcinoma, Gallbladder	`cholangiocarcinoma` → Cholangiocarcinoma only ×3 `gall[-\s]?bladder` → Gallbladder cancer only ×0 anything else → any site ×4	cholangiocarcinoma → Cholangiocarcinoma; gallbladder cancer → Gallbladder
Neuroendocrine tumoursSite	Pancreatic, Gastrointestinal, Lung	`gastro-?entero-?pancreatic\|\bgep[-\s]?nets?\b` → Gastroenteropancreatic NET only ×1 `extra[-\s]?pancreatic` → Extra-pancreatic NET only ×1 `well[-\s]?differentiated.*pancrea` → Well-differentiated pancreatic NET only ×1 `pancrea` → Pancreatic NET only ×3 `gastro\|intestin\|midgut\|stomach\|colo\|rect\|appendi` → Gastrointestinal NET only ×1 `lung\|bronch\|pulmonary\|thymic` → Lung NET only ×1 anything else → any site ×0	pancreatic net → Pancreatic; gastrointestinal net → Gastrointestinal; lung net → Lung
Prostate cancerCastration status	Hormone-sensitive, Castration-resistant	`castrat\w[-\s]?resistant\|\bcrpc\b` → Castration-resistant only ×16 `hormone[-\s]?(?:sensitive\|dependent)\|castrat\w[-\s]?sensitive\|\b[hc]spc\b` → Hormone-sensitive only ×9 anything else → any castration status ×6	hormone-sensitive → Hormone-sensitive; castration-resistant → Castration-resistant
Urothelial carcinomaMuscle invasion	Non-muscle-invasive, Muscle-invasive	`non[-\s]?muscle[-\s]?invasive.*carcinoma in situ` → Non-muscle-invasive with carcinoma in situ only ×1 `non[-\s]?muscle[-\s]?invasive\|\bnmibc\b` → Non-muscle-invasive only ×1 `muscle[-\s]?invasive\|\bmibc\b\|\bmiuc\b` → Muscle-invasive only ×7 anything else → any muscle invasion ×11	non-muscle-invasive → Non-muscle-invasive; muscle-invasive → Muscle-invasive
GliomaGrade	Low-grade, High-grade, SEGA	`subependymal giant cell` → SEGA with tuberous sclerosis only ×1 `grade 2\|grade ii\b` → Grade 2 only ×4 `low[-\s]?grade` → Low-grade glioma only ×4 `high[-\s]?grade\|glioblastoma\|grade [34]` → High-grade glioma only ×2 anything else → any grade ×0	low-grade glioma → Low-grade; high-grade glioma → High-grade; sega → SEGA
Non-small cell lung cancerHistology	Squamous, Non-squamous	`non[-\s]?squamous` → Non-squamous only ×9 `squamous` → Squamous only ×4 `adenocarcinoma` → Adenocarcinoma only ×1 anything else → any histology ×70	squamous cell carcinoma → Squamous; non-squamous → Non-squamous; adenocarcinoma → Non-squamous
MesotheliomaHistology	Epithelioid, Non-epithelioid	`non[-\s]?epithelioid\|sarcomatoid\|biphasic` → Non-epithelioid only ×1 `epithelioid` → Epithelioid only ×0 anything else → any histology ×2	epithelioid → Epithelioid; non-epithelioid → Non-epithelioid; sarcomatoid → Non-epithelioid; biphasic → Non-epithelioid
MesotheliomaSite	Pleural, Peritoneal	`pleura` → Pleural mesothelioma only ×3 `periton` → Peritoneal mesothelioma only ×0 anything else → any site ×0	pleural → Pleural; peritoneal → Peritoneal
Ovarian cancerHistology	High-grade serous, Other high-grade, Low-grade	`high[-\s]?grade serous` → High-grade serous only ×2 `high[-\s]?grade` → High-grade only ×6 `low[-\s]?grade` → Low-grade only ×0 anything else → any histology ×4	high-grade serous → High-grade serous; high-grade → High-grade serous or Other high-grade; other high-grade → Other high-grade; low-grade → Low-grade; serous → High-grade serous or Low-grade; clear cell → Other high-grade; endometrioid → Other high-grade or Low-grade
Ovarian cancerPlatinum	Platinum-sensitive, Platinum-resistant	`platinum[-\s]?resistant` → Platinum-resistant only ×0 `platinum[-\s]?sensitive` → Platinum-sensitive only ×0 anything else → any platinum ×12	platinum-sensitive → Platinum-sensitive; platinum-resistant → Platinum-resistant
Renal cell carcinomaHistology	Clear cell, Non-clear cell	`non[-\s]?clear[-\s]?cell\|papillary\|chromophobe` → Non-clear cell only ×0 `clear[-\s]?cell` → Clear cell only ×1 anything else → any histology ×24	clear cell → Clear cell; non-clear cell → Non-clear cell; papillary → Non-clear cell; chromophobe → Non-clear cell
Thyroid cancerHistology	Differentiated, Medullary, Anaplastic	`medullary` → Medullary thyroid cancer only ×3 `anaplastic` → Anaplastic thyroid cancer only ×0 `(?<!poorly )differentiated\|papillary\|follicular` → Differentiated thyroid cancer only ×5 anything else → any histology ×1	differentiated → Differentiated; papillary → Differentiated; medullary → Medullary; anaplastic → Anaplastic
Soft tissue sarcomaSubtype	DFSP, Other sarcomas	`dermatofibrosarcoma` → Dermatofibrosarcoma protuberans only ×1 anything else → any subtype ×2	dfsp → DFSP; other sarcomas → Other sarcomas
Acute myeloid leukaemiaSubtype	APL, t-AML or AML-MRC, Other AML	`de novo\b[^.]*\bexcept (?:acute promyelocytic\|apl\b)` → De novo AML except APL ×0 `\b(?:except\|other than\|excluding) (?:acute promyelocytic\|apl\b)` → Except APL ×0 `promyelocytic\|\bapl\b` → Acute promyelocytic leukaemia only ×4 `therapy[-\s]?related\|myelodysplasia[-\s]?related\|\bt-aml\b\|aml-mrc` → Therapy-related AML or AML with myelodysplasia-related changes only ×0 anything else → any subtype ×11	acute promyelocytic leukaemia → APL; t-aml or aml-mrc → t-AML or AML-MRC; other aml → Other AML
Chronic myeloid leukaemiaPhase	Chronic phase, Accelerated phase, Blast phase	`chronic(?: phase)?,? accelerated(?: phase)?,? (?:or\|and) blast` → Chronic phase or Accelerated phase or Blast phase, not shown ×0 `chronic(?: phase)? or accelerated` → Chronic or accelerated phase only ×0 `chronic phase\b.*\b(?:accelerated\|blast)` → Chronic phase or Accelerated phase or Blast phase, not shown ×0 `accelerated(?: phase)? (?:or\|and) blast` → Accelerated or blast phase only ×1 `lymphoid blast` → Lymphoid blast phase only ×0 `chronic phase\|\bcml-cp\b` → Chronic phase only ×6 anything else → any phase ×17	chronic phase → Chronic phase; accelerated phase → Accelerated phase; blast phase → Blast phase
Myeloproliferative neoplasmsDisease	Myelofibrosis, Polycythaemia vera, Essential thrombocythaemia, HES or CEL	`myelofibrosis` → Myelofibrosis only ×6 `polycyth` → Polycythaemia vera only ×4 `thrombocyth` → Essential thrombocythaemia only ×1 `eosinophil` → HES or CEL only ×1 anything else → any disease ×0	myelofibrosis → Myelofibrosis; polycythaemia vera → Polycythaemia vera; essential thrombocythaemia → Essential thrombocythaemia; hes or cel → HES or CEL
Systemic mastocytosisSubtype	Advanced, Indolent	`indolent\|smou?ldering` → Indolent systemic mastocytosis only ×1 `aggressive\|associated ha?ematological\|sm-ahn\|mast cell leuk\|\bmcl\b\|\basm\b\|advanced` → Advanced systemic mastocytosis only (ASM, SM-AHN or MCL) ×6 anything else → any subtype ×0	advanced systemic mastocytosis → Advanced; indolent systemic mastocytosis → Indolent
Multiple myelomaStage	Smouldering, Multiple myeloma	`smou?ldering` → Smouldering myeloma only (high risk) ×1 `myeloma` → Multiple myeloma, not shown ×39 anything else → any stage ×0	smouldering myeloma → Smouldering; multiple myeloma → Multiple myeloma
Acute lymphoblastic leukaemiaLineage	B-cell, T-cell	`b[-\s]?cell\|precursor\|\bb-all\b` → B-cell precursor ALL only ×11 `t[-\s]?cell\|\bt-all\b` → T-cell ALL only ×0 anything else → any lineage ×9	b-cell all → B-cell; t-cell all → T-cell
Hodgkin lymphomaType	Classical, Nodular lymphocyte-predominant	`classical` → Classical Hodgkin lymphoma only ×4 `nodular lymphocyte` → Nodular lymphocyte-predominant only ×0 anything else → any type ×4	classical hodgkin lymphoma → Classical; nodular lymphocyte-predominant hodgkin lymphoma → Nodular lymphocyte-predominant
Large B-cell lymphomaSubtype	DLBCL, HGBL, PMBCL, FL3B	`grade 3b\|\bfl3b\b` → Follicular lymphoma grade 3B only ×0 `\bnos\b\|not otherwise specified` → DLBCL NOS only ×1 `primary mediastinal\|\bpmbcl\b` → PMBCL only ×3 `high[-\s]?grade\|\bhgbl\b` → HGBL only ×3 `diffuse large\|\bdlbcl\b` → DLBCL only ×14 anything else → any subtype ×0	dlbcl → DLBCL; hgbl → HGBL; pmbcl → PMBCL; fl grade 3b → FL3B
Follicular lymphomaGrade	Grade 1–3A, Grade 3B	`grade 3b\|\bfl3b\b` → Grade 3B only ×2 `grade 1[-–\s]+3a` → Grade 1–3A only ×1 anything else → any grade ×17	fl grade 1–3a → Grade 1–3A; fl grade 3b → Grade 3B
T-cell lymphomaSite	Cutaneous, Systemic	`cutaneous\|mycosis\|s[ée]zary\|\bctcl\b` → Cutaneous T-cell lymphoma only ×4 `anaplastic large cell\|\balcl\b` → Systemic ALCL only ×3 `systemic\|peripheral\|\bptcl\b\|nodal` → Systemic T-cell lymphoma only ×0 anything else → any site ×0	cutaneous t-cell lymphoma → Cutaneous; systemic t-cell lymphoma → Systemic