Test method (extracted)

2. No biomarker in the text (classic chemotherapy, anti-angiogenesis without biomarker gating) → biomarker_name="none", alteration_type="none", biomarker_detail="n/a", diagnostic_criterion="n/a", scoring_system="n/a", test_method=[] (empty list — no diagnostic test applies). Flag "no-biomarker" and "non-targeted-therapy".

2a. A hereditary tumour syndrome named as the population (von Hippel-Lindau disease, neurofibromatosis type 1, tuberous sclerosis complex) is a clinical diagnosis, not a biomarker: biomarker_name="none", alteration_type="none", scoring_system="n/a", test_method=[]. Put the syndrome into tumor_type (e.g. "VHL disease-associated renal cell carcinoma") and patient_eligibility, and flag "no-biomarker" but NOT "non-targeted-therapy". Record a germline biomarker only when the text names the alteration itself (e.g. "germline BRCA1/2 mutations").

7. Gene symbols uppercase (BRAF, EGFR, ERBB2). Use "PD-L1" (protein) not CD274. An HLA type is a germline genotype, never a mutation: "HLA-A*02:01-positive" → biomarker_name="HLA-A*02:01", alteration_type="overexpression", biomarker_detail="HLA-A*02:01-positive", scoring_system="n/a", test_method=["molecular"]. Hormone receptors are proteins measured by IHC: "hormone receptor-positive" → biomarker_name="HR", "oestrogen receptor-positive" → "ER", progesterone receptor → "PR"; use "ESR1" only for ESR1 mutations.

16. `test_method` is a workflow-level descriptor — what kind of pathology lab test the indication implies. Pick from:
    - "IHC" — protein expression by immunohistochemistry (PD-L1, HER2 IHC, MMR proteins, ER/PR).
    - "ISH" — in situ hybridization, umbrella for FISH/CISH/SISH (HER2 amplification, ALK/ROS1 fusions when ordered as FISH).
    - "molecular" — any DNA/RNA assay regardless of platform: PCR, Sanger sequencing, NGS, ddPCR (mutation detection like EGFR/BRAF/KRAS, fusion detection by RNA-seq, MSI by PCR).
    - "cytogenetics" — conventional karyotype / cytogenetic analysis (heme malignancies).
    - "flow-cytometry" — phenotypic marker detection in heme (e.g. CD30, CD20, CD22).
    Multiple values are valid when the criterion is algorithmic (HER2: ["IHC", "ISH"]). Empty list `[]` when biomarker_name="none" — no test applies.